Abstract
The role of prostaglandin synthesis was evaluated by indomethacin administration in
the pathogenesis of exercise-induced muscle fiber injuries in soleus and quadriceps
femoris muscles of mice. The administration of indomethacin before, during, and after
9 h exertion (s.c, 6 mg/kg during and just after exertion and 1.5-3 mg/kg before exertion
and later twice a day) caused a significant histologic protection against exercise
injuries and considerably reduced the exercise responses of β-glucuronidase and glucose-6-phosphate
dehydrogenase activities (enzymatic indicators of necrotic lesions in skeletal muscles)
on the 2nd post-exercise day. The administration of indomethacin before and during
the exertion (3 and 10 mg/kg, respectively) but not after exertion caused only a slight
histologic protection while the enzymatic indicators showed a nonsignificant effect.
Key words
skeletal muscles - exertion - indomethacin - exercise injuries - prostaglandins
